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The decreased levels of betaine and betaine: choline ratio and increased DMG: betaine ratio in the COC user group indicate upregulation of the methylation cycle and are consistent with the results obtained by Rios-Avila et al

doi: 10.1007/s10142-017-0579-3

Five plasma samples from 998 subjects requiring chronic transfusion support for anemia and 12 plasma samples from 10,721 general hospital subjects never exposed to amustaline/GSH RBC demonstrated low titer reactivity with amustaline/GSH RBCs